What is Paget’s Disease

Paget’s disease of bone interferes with your body’s normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen. Paget’s disease of bone most commonly occurs in the pelvis, skull, spine and legs. Paget’s disease of bone most commonly occurs in the pelvis, skull, spine, and legs. Risk factors include increasing age and a family history of the condition. Over time, affected bones may become fragile and misshapen.