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What is Cadasil Syndrome

Cadasil syndrome is a rare disease characterized by migraine headaches and multiple strokes, which progresses to dementia. A rare disease involving cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is the most common form of hereditary stroke disorder, and is thought to be caused by mutations of the Notch 3 gene on chromosome 19. Blood Testing can diagnose >95% of cases of CADASIL with certainty. The method involves a blood test sent to a specialized laboratory. Availability of the test result makes diagnosis of other family members relatively easy. Prior to availability of the gene tests, skin biopsy was used to diagnose CADASIL. Consult a doctor for medical advice.

Symptoms

  • CADASIL is characterized by migraine headaches and multiple strokes, which progresses to dementia
  • white matter lesions throughout the brain
  • cognitive deterioration
  • seizures
  • vision problems
  • Mental Challenges such as severe depression and changes in behavior and personality

Treatment

  • Although it has not been tested specifically in CADASIL patients most doctors would recommend that patients with CADASIL take a small dose of aspirin per day (75-300mg).
  • Medications to reduce blood clotting, such as Dipyridamole (Persantin) and Clopidogrel (Plavix).
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